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Cartesian Dualism was dealt severe blow by Newton (https://youtu.be/D5in5EdjhD0) and has been effectively disproved by John Conway's Free Will Theorem where he shows that if humans have free will (in a very general sense he defines precisely) then so do subatomic particles under very conservative assumptions (properties of quantum mechanics and special relativity which have been extremely well verified experimentally). And he makes an interesting philosophical argument for human free will from this https://www.youtube.com/watch?v=IgvkhgE1Cps

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